Tyler W. LeBaron, founder of the science-based nonprofit Molecular Hydrogen Institute, is one of the most knowledgeable people about molecular hydrogen and its benefits. There are so many benefits we can learn from him and many other researchers from Universities around the world. For starters, H2 is a potent selective antioxidant. This is important, as many other antioxidants, such as vitamin C and E are not selective, and when taken in excess, can be counterproductive. Hydrogen doesn't have that downside, which is one of the reasons why it's my favorite. Now, when we talk about molecular hydrogen, we are talking about the gas, the H2 molecule, which is two hydrogen atoms bound together. The H2 molecule is the smallest in the universe, which allows it to diffuse through all cell membranes, including the blood-brain barrier and subcellular compartments, and into the mitochondria. It doesn't need any transporter protein. It also has no charge or polarity. As explained by LeBaron, that's critical, because charged molecules cannot easily penetrate cell membranes. Charged molecules must go through a protein channel. All of this gives it superior cellular bioavailability. Health Benefits of H2Among the many health benefits of H2 is its ability to decrease excessive oxidative stress, inflammation and perturbations from normal homeostasis. The key word here is "excess," because some oxidative stress and some free radicals are actually beneficial. For example, you metabolize food through the process of oxidation, and that oxidation is necessary for life to exist. So, what we're looking for in terms of health is the ability to inhibit excessive oxidative stress and damage. LeBaron reviews this in greater detail in the interview so, for more information, please listen to it in its entirety, or read through the transcript. As just one example, certain therapies such as photobiomodulation, exercise and sauna bathing mildly increase oxidation in the body, and that oxidation is what induces various beneficial effects such as the induction of heat shock proteins (HSP). This process is known as hormesis.
H2 Is a Selective AntioxidantWhen it comes to oxidative stress, all you really want is a return to homeostasis. You don't want to neutralize all free radicals. Many antioxidants have a high number of electrons that can easily and indiscriminately scavenge, react with and neutralize a wide range of radicals or oxidants. Molecular hydrogen, on the other hand, is selective, and thus only eliminates the excess, so that homeostasis is restored.
On the other hand, H2 readily reacts with the toxic hydroxyl radical — the most reactive and oxidative radical in the body — turning it into harmless water. Studies suggest H2 may be very helpful in cases of heart attack or stroke, for example, protecting against the oxidative damage from hydroxyl radicals that occur during reperfusion.1 In my view, molecular hydrogen should be implemented ASAP in all cases of heart attack and stroke for this reason. There's no risk, it's very inexpensive and the upside potential is enormous. LeBaron cites animal research published in the Journal of the American Heart Association2 showing H2 administration increased the post-cardiac arrest syndrome survival rate from 43% in the control group to 92% in the H2 group. When combined with therapeutic hypothermia, which inhibits the creation of free radicals, the survival rate shot up to 100%. It simply doesn't get any better than that. According to LeBaron, the Japanese government has now approved the inhalation of H2 gas as an advanced medicine for the treatment of post-cardiac arrest syndrome.3 He also reviews some of the studies that are currently underway to investigate the benefits of molecular hydrogen inhalation during heart surgery and other instances. H2 Is a Signal ModulatorAside from being a selective antioxidant, H2 acts as a gaseous-signal modulator, and thus is able to influence gene expression and protein phosphorylations cascades involved in signal transduction, all of which help explain its therapeutic effects. One of the primary pathways that H2 activates is the Nrf2 pathway. LeBaron explains:
Importantly, though, contrary to other Nrf2 activators, H2 only activates Nfr2 if it's actually needed. In this way, the risk of it suppressing beneficial free radicals like nitric oxide is minimized. Indeed, H2 appears to be one of the safest therapeutic options available. It's downside potential is almost nonexistent.
How to Administer H2The easiest way to get hydrogen gas into your system is to dissolve a molecular hydrogen tablet in water and drink it. In the interview, LeBaron warns us why we need to be skeptical and cautious about electrolysis machines, as they often don't produce anywhere near the concentrations required. In clinical studies this is often 1.6 mg/L and above, which at first doesn't sound like very much, but it is significant as LeBaron further explains:
Research has shown H2 water can improve nonalcoholic fatty liver disease4 and metabolic syndrome,5 both of which are diet-driven conditions. In a recent study6 looking at metabolic syndrome, a high dose of H2 was used using hydrogen-producing tablets. The study involved 60 subjects and lasted for six months and "significantly reduced blood cholesterol and glucose levels, attenuated serum hemoglobin A1c, and improved biomarkers of inflammation and redox homeostasis." It even "tended to promote a mild reduction and body mass index and hip-to-waist ratio," the study authors added.
Concentration and Frequency MatterAside from making sure the concentration is sufficiently high, you also want to pulse your intake, as the more continuous the exposure, the less effective it is. LeBaron further explains:
Clearly, the studies need to be done to determine the best frequency, but until then, it would seem that customizing the dose to your personal circumstances might be more appropriate. So, if you're in normal, nonstressful circumstances at home, not exercising much at all, then maybe once day is sufficient. On the other hand, if you exercise vigorously then it might be more appropriate to take it a couple of times a day. If you travel by airplane, taking it every two hours while flying might be appropriate. The good news is, H2 is quite safe, so you're unlikely to do harm. Another benefit when using hydrogen tablets is that they contain highly bioavailable unbound magnesium ions. Each tablet will provide about 80 mg of ionic magnesium, which is about 20% of the RDA. Synergistic Effects With Other TherapiesH2 gas can also be used together with other supplements and therapies for a potential synergistic effect. For example, you can take it along with a sauna, both of which produce heat shock proteins, or with nutritional ketosis or exogenous ketones. Another example is hyperbaric oxygen therapy.
Similarly, H2 gas can both increase and decrease mTOR activation,13,14 depending on what your body needs. Ditto for IgF1.15,16 What this means is that if you're fasting or doing time-restricted eating, which activates autophagy, taking molecular hydrogen not only can optimize autophagy, but also lower it if too much is taking place. That could make long-term fasting much safer. What's more:
Dosing BasicsThe normal dose is one tablet — which is considered an appropriately high dose — in 500 mL or 16 ounces of water. That will give you a concentration of about 10 mg of H2 per liter (10 mg/L), which means you're getting a dose of 5 mg. As soon as the tablet has dissolved, you'll want to drink the whole glass before the cloud of H2 gas dissipates. The rate at which it dissolves can vary from anywhere from one to two or three minutes, depending on how cold the water is. If you put it in iced water, it's going to take even longer. Ideally, use room temperature water, as the colder it is, the longer it takes for the tablet to dissolve, and the longer it takes, the less of the gas will remain by the time the tablet is fully dissolved. Also, use still water, not sparkling water, which has CO2 dissolved in it, as that will disperse the H2 gas out faster. You want to drink it as quickly as possible while it still has that milky look. The white cloudiness is the suspended hydrogen. If you wait until the water turns clear, the hydrogen gas has evaporated away. Again, if your body is under serious stress, you may take four or five tablets a day. If not, a single tablet a day would probably be sufficient. For more information about molecular hydrogen research, visit the National Institutes of Health library20 and search for molecular hydrogen. Also be sure to check out the Molecular Hydrogen Institute's website. from http://articles.mercola.com/sites/articles/archive/2020/06/28/tyler-lebaron-molecular-hydrogen.aspx
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