Quercetin1 is an antioxidant flavonol found naturally in foods such as apples, plums, red grapes, green tea, elder flower and onions, just to name a few.2 According to a 2019 Market Watch report,3 the quercetin market is growing rapidly as its health benefits are becoming more widely known. Quercetin has been shown to combat inflammation and acts as a natural antihistamine. In fact, its antiviral capacity appears to be the primary focus of many studies looking at quercetin's benefits, and a number of studies have highlighted quercetin's ability to prevent and treat both the common cold and influenza.4,5,6,7 But there are also other, less known benefits and uses for this supplement, including the prevention and/or treatment of:8
Additionally, quercetin is also helpful for aluminum-induced neurodegenerative changes, such as those seen in Alzheimer's, Parkinson's and amyotrophic lateral sclerosis (ALS). As noted in a 2016 study:19
Quercetin Improves Metabolic Syndrome TraitsAmong the most recent papers on this powerful antioxidant is a review20 published in the March 2019 issue of Phytotherapy Research, which looked at nine randomized controlled trials investigating quercetin's effect on metabolic syndrome. Metabolic syndrome refers to a cluster of conditions (including high blood pressure, high blood sugar, high triglyceride levels and fat accumulation around the waist) that raise your risk for Type 2 diabetes, heart disease and stroke. While pooled findings found no effect on fasting plasma glucose, insulin resistance or hemoglobin A1c levels, further subgroup analyses revealed quercetin supplementation "significantly reduced" fasting plasma glucose in studies lasting at least eight weeks and in which dosages of at least 500 milligrams (mg) per day were used. In studies that included people over the age of 45, "significant" reductions in insulin were also found when using a dosage of 500 mg per day or more. An earlier study,21 published in 2011, looked at quercetin's effects on certain traits of metabolic syndrome. This study focused specifically atherosclerosis and inflammation in men with the APOE genotype 3/3, 3/4 and 4/4, and found quercetin significantly decreased waist circumference, postprandial systolic blood pressure, postprandial triacylglycerol, and increased HDL-cholesterol compared to placebo. Here, participants were given 150 mg of quercetin per day for eight weeks. Research22 on obese rats published in 2008 also found that quercetin supplementation at doses of 2 mg per kilo or 10 mg/kg of body weight for 10 weeks improved systolic blood pressure, triglyceride, total cholesterol and free fatty acid levels. The 10 mg/kg dose also improved the animals' inflammation status. As noted by the authors:
One of the first studies23 to demonstrate quercetin's beneficial effects on blood pressure was published in 2007. As reported by the authors:
Similarly, a January 2020 systematic review24 of 17 studies concluded quercetin "significantly decreased" blood pressure in human subjects. Those who took it for eight weeks or more also had "significantly" improved high-density lipoprotein cholesterol and triglycerides. Quercetin Improves Diabetes-Induced NAFLDOther recent research25 published in the August 2019 issue of Phytotherapy Research concluded quercetin has a beneficial impact on NAFLD "by ameliorating inflammation, oxidative stress and lipid metabolism." Diabetes can play a role in NAFLD as well, showing just how influential insulin resistance is in the development of chronic diseases of all kinds. As explained in the abstract:
Quercetin Helps Modulate Gene ExpressionAccording to research26 published in 2016, quercetin even has the ability to trigger tumor regression by interacting with your DNA and activating the mitochondrial pathway of apoptosis (the programmed cell death of damaged cells). Quercetin was found to induce cytotoxicity in leukemic cells, and the effect was dose-dependent. Limited cytotoxic effects were also found in breast cancer cells. Overall, quercetin increased the life span in cancer-ridden mice fivefold compared to untreated controls. The authors attributed these effects to quercetin's direct interaction with DNA and its activation of the mitochondrial pathway of apoptosis, and suggested quercetin's potential use as a cancer therapy adjunct deserves further exploration. More recent research27 in the journal Molecules also highlights quercetin's epigenetic influence and ability to:
MicroRNAs used to be considered "junk" DNA. Far from being useless, research has now revealed that "junk" DNA is actually microRNA and plays a crucial role in regulating genes that make the proteins that build your body. The microRNA function as "on/off" switches for the genes. Depending on the microRNA input, a single gene can code for any of more than 200 protein products. Quercetin's ability to module microRNA may also help explain its cytotoxic effects, and why it appears to improve cancer survival (at least in mice). Quercetin Is a Powerful AntiviralAs mentioned, one of the most well-studied attributes of quercetin is its antiviral capacity, which have been attributed to three main mechanisms of action:
For example, research28 funded by the U.S. Department of Defense, published in 2007, found it lowers your risk of viral illness and boosts mental performance following extreme physical stress, which might otherwise undermine your immune function and render you more susceptible to infections. Here, cyclists who received a daily dose of 1,000 mg of quercetin in combination with vitamin C (which enhances plasma quercetin levels29,30) and niacin (to improve absorption) for five weeks were significantly less likely to contract a viral illness after bicycling three hours a day for three consecutive days, compared to untreated controls. While 45% of the placebo group got sick, only 5% of the treatment group did. In another study31 funded by the U.S. Defense Advanced Research Projects Agency (DARPA), published in 2008, animals treated with quercetin were challenged with a highly pathogenic H1N1 influenza virus. Again, the treatment group had significantly lower morbidity and mortality than the placebo group. A number of other studies have also confirmed quercetin's effectiveness against a variety of viruses, including the following:
Quercetin Combats Inflammation and Boosts ImmunityAside from its antiviral activity, quercetin is also known for boosting immunity and combating inflammation. As noted in a 2016 study43 in the journal Nutrients, mechanisms of action include (but is not limited to) the inhibition of:44 • Lipopolysaccharide (LPS)-induced tumor necrosis factor α (TNF-α) production in macrophages. TNF-α is a cytokine involved in systemic inflammation, secreted by activated macrophages, a type of immune cell that digests foreign substances, microbes and other harmful or damaged components • LPS-induced mRNA levels of TNF-α and interleukin (IL)-1α in glial cells, which results in "diminished apoptotic neuronal cell death" • The production of inflammation-producing enzymes • Calcium influx into the cell, which in turn inhibits: ◦ Pro-inflammatory cytokine release ◦ Histamine and serotonin release from intestinal mast cells release45 According to this paper, quercetin also stabilizes mast cells, has cytoprotective activity in the gastrointestinal tract, and "a direct regulatory effect on basic functional properties of immune cells," which allows it to inhibit "a huge panoply of molecular targets in the micromolar concentration range, either by down-regulating or suppressing many inflammatory pathways and functions."46 Quercetin May Be a Useful Supplement for ManyConsidering its wide-ranging benefits, quercetin may be a useful supplement for many, either acutely or more long-term. It's one of the supplements I recommend keeping in your medicine chest for times when you feel you're "coming down" with something, be it the common cold or influenza. If you're prone to colds and flu, you could consider taking it for a couple of months before cold and flu season hits to boost your immune system. More long-term, it appears useful for those with metabolic syndrome, although it would be foolish to rely on any given supplement without also addressing more fundamental strategies such as diet and exercise. As explained in my 2015 interview with Dr. Robert Lustig, sugar has been shown to be a causative factor in insulin resistance, which is a hallmark of metabolic syndrome and a risk factor for virtually all chronic disease. If you have one or more of the conditions that make up metabolic syndrome, you'd be wise to limit your total sugar consumption to 15 grams per day. If you're healthy, and want to stay that way, your daily sugar limit would be around 25 grams. You can learn more about this and related treatment strategies in "Vitamin D Can Significantly Lower Your Risk of Metabolic Syndrome." from http://articles.mercola.com/sites/articles/archive/2020/01/27/quercetin-benefits.aspx
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