While many professions have health risks, some have a particularly high risk for cancer. Female firefighters aged 40 to 50 are six times more likely to develop breast cancer than the national average, for example, thanks to the high levels of dioxins and furans firefighters are exposed to when flame-retardant chemicals burn. Shift workers are also at high risk for cancer due to disrupted circadian rhythms and inhibited melatonin production. In fact, the International Agency for Research on Cancer, a research arm of the World Health Organization, classified shift work as a probable human carcinogen in 2007.1 Another high-risk group is flight attendants, who have higher rates of cancer than the general population, and that includes every cancer examined. Flight Attendants Have Higher Risk for CancerWhile previous research has found flight attendants have higher rates of breast cancer and melanoma, recent research2,3 published in Environmental Health expands that list, noting the same trend for every cancer examined, including non-melanoma, uterine, cervical, gastrointestinal and thyroid cancers. Compared to the general population, female cabin crew report 1.5 times higher rates of breast cancer, over twice the melanoma and four times the rate of non-melanoma skin cancer. Interestingly, only male crew exposed to secondhand smoke had significantly higher rates of these cancers. According to the authors:
Breast cancer rates are also higher among flight attendants with multiple children, a finding that surprised researchers since childbirth and breastfeeding lower a woman's risk of breast cancer. According to the National Cancer Institute, a woman who has given birth to five or more children has half the risk of those who have not given birth.4 Risk Factors Associated With Frequent FlyingWhat's causing this elevated cancer risk in flight crews? Like shift workers, flight attendants often work irregular schedules, and circadian rhythm disruptions have already been identified as a risk factor for cancer.5 Other possible explanations include exposure to carcinogens such as pesticides, fire retardant chemicals and jet fuel, and exposure to high levels of cosmic ionizing radiation,6 all of which are known to raise your cancer risk. As a general rule, European aircrews are better protected from ionizing radiation, as exposure to ionizing radiation is monitored and doses are limited by law in Europe. No such dose limits exist for American flight crews. The goal of the present study was to gather evidence that can be used to, hopefully, create safer work rules for American airline workers. It's also worth noting that while few studies have assessed the risk faced by frequent fliers, there's reason to suspect their risk for cancer would be similar to that of flight attendants, although matching a flight attendant's frequency of flight would be a challenge for most frequent fliers. Cosmic Radiation Is a Significant Health Hazard in Large DosesAccording to the authors, the results suggest several environmental exposures — including ionizing radiation, circadian rhythm disruption, past exposure to secondhand smoke during flights (for those who worked during years prior to the in-flight smoking ban) and a variety of chemical agents with known carcinogenic potential — contribute to flight crews' elevated cancer risk, although ionizing radiation may be one of the most significant factors. On the issue of cosmic radiation, the researchers note:
My New Research PaperI am in the process of writing three books, and about three months ago I went on a deep dive tangent seeking to compile a coherent explanation of how EMFs damage your biology. I now believe I have compiled a unified explanation for how nonionizing and ionizing radiation exposure that occurs during commercial air travel causes DNA damage and, more importantly, how it can be effectively biologically remediated. I have read thousands of pages of detailed scientific studies thus far and have compiled a 50-page document with over 200 references. The paper has been reviewed by Dr. Martin Pall, Thomas Seyfried and an associate of Dr. Richard Veech, along with a few other molecular biologists, and I have gotten much positive feedback. There's still more work to be done, but I hope to publish the paper later this year and make it available to all. When I saw this recent study documenting the health effects of commercial air travel, I thought I should share some highlights of my paper. The damage observed in this study is largely a result of subatomic particles from the sun and deep space that bombard the Earth's atmosphere. When you are flying at 30,000 feet, reactions between those particles and the atmosphere produce secondary particles. Those secondary particles penetrate planes, and your skin, where they can damage your DNA unless you are properly protected. How Ionizing Radiation Causes DamageCommercial flight at 35,000 feet will expose you to ionizing radiation, but you are also exposed to them during X-rays. CAT scans are far worse and should be avoided if at all possible. MRIs typically can be substituted and do not damage your DNA like CAT scans do. So, the protocol I describe below not only can be used for air travel, but also for unavoidable X-ray exposures. There is no question that exposure to the high-energy frequencies of ionizing radiation will cause single and double strand breaks in your DNA. The real question is, how does your body repair the damage? Fortunately, we have built-in repair systems that can accomplish this. There is a family of 18 enzymes called poly ADP ribose polymerases (PARP) that function as DNA damage sensors. PARP binds to both single- and double-stranded DNA breaks.7 On binding to damaged DNA, PARP forms long branches of ADP-ribose polymers that may reach up to 200 units on target proteins such as histones and PARP itself.8 However, this repair process results in cellular energetic NAD+ depletion and, ultimately, when PARP is overactivated, necrosis by bioenergetic collapse. PARP was not known when I was in medical school. It was first described in 1963.9 When your DNA is damaged, PARP is activated to repair the damage. This activation, however, is correlated with loss of mitochondrial potential and decreases mitochondrial oxygen consumption along with steady reductions of cellular NAD+. This slows the rate of glycolysis, electron transport and ATP formation, and eventually leads to functional impairment or death of cells, as well as upregulation of various proinflammatory pathways, and in the worst case scenario, irreversible damage and necrotic cell death. If you didn't already know, NAD+ is one of the most important metabolic cofactors in all eukaryotic cells, as it plays a critical role in regulating cellular metabolism and energy homeostasis through redox balancing. NAD+ in its reduced form (NADH) serves as the primary electron donor in the mitochondrial transport chain resulting in ATP production.10 The key to note here is that the primary fuel for PARP is NAD+. It appears that if you supply your body with NAD+ by supplemental precursors, you can radically limit the damage the ionizing radiation will cause, as PARP will have enough fuel to repair the damage. I will discuss my new protocol for limiting this damage when you fly. It is still incomplete but will help many of you that regularly fly to avoid the biological consequences of the damage being done. How to Remediate Gamma Radiation While FlyingThere are actually three strategies that can be taken. The first is to augment NAD+ levels, the second is to increase your ketone levels and the third would be to activate the Nrf2 antioxidant pathway. • NAD+ -- There are four dietary NAD precursors: niacin, nicotinamide, nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). You can also use IV NAD+ but that is obviously not possible while flying, and I'm not sure I would advise it even if it were possible. The least expensive, and my best recommendation, is to take niacin. The only problem is that it will cause flushing, which is uncomfortable for most. Nearly everyone will develop flushing at 50 milligrams (mg) unless you've already developed tolerance. It is best to start with small doses of 25 mg and work your way up to 50 mg. The least expensive way is to purchase niacin powder and start with s tiny dose that doesn't cause you to flush and work your way up to one-sixteenth teaspoon. The advantage of the powder is a year's supply is under $20, and there are no fillers or flow agents like magnesium stearate. I would not advise nicotinamide, which does not cause a flush, as in higher doses it suppresses sirtuin activation. However, I do believe there is value in NR and I think 50 mg with the niacin is a good dose as they work synergistically to increase NAD+. I may change my mind in the future as I still have more material to evaluate, but at this time I prefer NR to NMN. • Ketones -- Ketones are another great strategy to lower oxidative damage from ionizing radiation. Unlike antioxidants such as vitamin E, C and glutathione, which are highly charged molecules that cannot easily penetrate cellular membranes if you supplement with them, ketones are readily transported into the cell via a monocarboxylate transporter, and once inside the cell ketones do their magic. Part of the magic is that they increase NADPH, which is the primary way that your antioxidants are recharged. NADPH supplies the electrons to recharge C, E and glutathione. But it gets even better, as ketones are potent histone deactylase (HDAC) inhibitors and activate FOXO3a, which causes your body to produce antioxidants inside your cells that can be readily recharged by the increased NADPH. So, how do you increase ketones? Well, if you are intermittently fasting you can typically get to 0.5 mmol. If you are on a five-day fast, you can get to 6 or even 8 mmol of ketones, but fasting is something that you can't conveniently do every time you fly but you can do a partial fast and not eat for at least 18 hours prior to your flight and don't eat until you land. This is my standard strategy when flying. But there are also supplements such as ketone esters and salts that can increase your levels to 0.5 to as high as 8 mmol. The esters are far more effective but also far more expensive. The D isomers likely are far superior to the racemic versions. They are pricey though and cost $1/gram and one typically needs 15-25 grams. KetonAid is a good example. I will discuss these more in future newsletters, as this is a new field and there are new supplements that are coming to the market. You might be interested to know that NASA is currently testing the use of ketones for the space program to decrease oxidative damage in space. • Nrf2 Activation -- The Nrf2 is the master antioxidant pathway that regulates the expression of antioxidant proteins that protects you against oxidative damage triggered by injury and inflammation. It is similar in many ways to FOXO3a. You can activate this pathway with healthy cruciferous vegetables like broccoli sprouts that are loaded with sulforaphane. Other easy ways to activate it would be through molecular hydrogen. I prefer the high dose (9 mg/liter) nanobubble tablets that you can take several hours before your flight, as it takes a number of hours for them to maximize their antioxidant expression. CBD is also another excellent Nrf2 activator, but it also takes several hours to be maximally effective. • Exercise -- If you don't want to take any supplements, even ones that cost less than a penny (niacin), then consider exercise. Actually, I believe exercise is a crucial component of this and would recommend doing the Nitric Oxide Dump while you are waiting for your luggage. Ideally, you could do it also before you board the plane but you may garner some stares. Nevertheless, I regularly do this before and after flights. We all know exercise is fundamental to good health, but why is it good for DNA damage from ionizing radiation? Very simply, exercise is known to stimulate the transcription factor PGC-1 alpha, which is the most potent stimulus for mitochondrial biogenesis known, and we all appreciate how fundamental mitochondria are to your health. But PGC 1-alpha also activates FOXO3s and Nrf2 that cause your body to produce more glutathione, superoxide dismutase and catalase, which will radically lessen the oxidative damage from the ionizing radiation. Simple Strategies Can Lower Your Cancer RiskWhile the recommendations above apply to airline workers and frequent fliers specifically before and during flight, there are also a number of other lifestyle strategies that can help lower your risk of cancer. If you're in the air a lot, you'd be wise to tackle your risk from several angles, including the basics below:
Blood Tests That Help Reveal Your Cancer RiskWhile a healthy diet and lifestyle are recommended for everyone, a number of standard blood tests can help you determine your cancer risk, thereby putting you on notice that more radical lifestyle intervention may be prudent. Dr. Leigh Erin Connealy, whom I've interviewed on this topic, details these tests in her book, "The Cancer Revolution: A Groundbreaking Program to Reverse and Prevent Cancer." Valuable blood tests include: • High-sensitivity C-reactive protein (CRP) test, which is a nonspecific marker for inflammation. Ideally, you'll want your C-reactive protein to be below 1. • Hemoglobin A1C test, which reflects your blood sugar over the past 90 days. The reason for this test is because high blood sugar is a cancer-friendly environment • A cancer profile test (fasting blood and urine) from American Metabolic Laboratories, which checks for:
• ONCOblot, which can identify up to 33 tissue types of cancer and has a 95 percent accuracy rate. It measures the ENOX2 protein • Circulating tumor cell test by the Research Genetic Cancer Center. The vast majority of people die not from the tumor itself but from circulating cancer stem cells, which allow the cancer to metastasize and spread throughout the body. This test is used after cancer treatment, to determine whether or not you might need to continue an anticancer program from http://articles.mercola.com/sites/articles/archive/2019/02/27/flight-attendants-radiation-exposure.aspx
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